Court: U.S. Court of Appeals for the Federal Circuit

Docket: 23-2186 

Opinion Date: June 11, 2025

Judge: Sharon Prost

Agilent Technologies, Inc. appealed two final written decisions by the Patent Trial and Appeal Board (Board) that determined all claims of U.S. Patent Nos. 10,337,001 and 10,900,034 to be unpatentable. The patents in question relate to CRISPR-Cas systems for gene editing, specifically focusing on chemically modified guide RNAs (gRNAs) used in these systems. The Board found that the claims were anticipated by prior art, specifically a reference known as Pioneer Hi-Bred, and that certain claims were also obvious in view of additional references, Threlfall and Deleavey.

The Board’s decisions were based on findings that Pioneer Hi-Bred disclosed the claimed gRNA functionality and that the reference was enabling. The Board also found that the additional references provided sufficient motivation and reasonable expectation of success for a person of ordinary skill in the art to combine the teachings of Pioneer Hi-Bred with those of Threlfall and Deleavey.

The United States Court of Appeals for the Federal Circuit reviewed the Board’s findings. The court affirmed the Board’s determination that Pioneer Hi-Bred disclosed the claimed gRNA functionality, noting that substantial evidence supported the Board’s findings. The court also agreed with the Board’s conclusion that Pioneer Hi-Bred was an enabling reference, rejecting Agilent’s arguments that undue experimentation would be required to practice the disclosed invention.

Additionally, the court upheld the Board’s finding that the dependent claims, which included specific chemical modifications, were obvious in view of the combined teachings of Pioneer Hi-Bred, Threlfall, and Deleavey. The court found that the Board had provided a thorough analysis and that substantial evidence supported the Board’s conclusion that a person of ordinary skill in the art would have had a reasonable expectation of success in making the claimed modifications.

In conclusion, the Federal Circuit affirmed the Board’s decisions, holding that all claims of the ‘001 and ‘034 patents were unpatentable.